Herijgers, P., V. Leunens, T. B. Tjandramaga, K. Mubagwa and W. Flameng. Changes in organ perfusion after brain death in the rat and its relation to circulating catecholamines. Transplantation. 62:330-335, 1996.
Brain death can have an impact on donor organ function, This is often attributed to an altered hormonal, mainly thyroidal, status after brain death, A second possible explanation is that during the brain death process, blood flow is redistributed, causing ischemic damage in underperfused organs or regions, We investigated blood flow redistribution with colored microspheres in the Pat, early and. late after brain death, induced by inflation of an intracranial balloon, and correlated this with the global hemodynamic situation and plasma catecholamine concentrations, Brain death was proven by the demonstration of lasting absence of brain perfusion in all animals, Myocardial blood flow closely followed the myocardial oxygen need as estimated by the rate-pressure product, The abdominal organs showed intense vasoconstriction early after brain death, which led to significantly decreased perfusion of these organs despite the highly increased perfusion pressure, followed by significant vasodilation, Total plasma catecholamine concentration was 51 times higher at 30 sec after brain death as compared with basal levels, Plasma noradrenaline concentration fell significantly below basal levels late after brain death. We conclude: that brain death importantly alters regional perfusion, with possible implications Tar donor organ function, These changes are probably due to the tremendous alterations in the activity of the sympathetic nervous system. [References: 21].