Xuan, B., Y. H. Zhou, R. Varma and G. C. Y. Chiou. Effects of some N-nitropyrazole derivatives on ocular blood flow and retinal function recovery after ischemic insult. Journal of Ocular Pharmacology and Therapeutics. 15:135-142, 1999.

Ocular blood flow and retinal function were determined in this study with colored microspheres and b-wave amplitude of electroretinography, respectively. It was found that N-nitropyrazole analogs can facilitate the retinal function recovery efficiently after ischemic insult primarily through increase of choroidal blood flow specifically. Since age-related macular degeneration (AMD) is caused mainly by the choroidal vascular abnormality and/or insufficiency, these N-nitropyrazole analogs are of potential use in the treatment of AMD.